PUBLICATIONS

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UNCOVERING PROTEOLYTIC FUNCTION OF BONE ENDOTHELIUM

Romeo SG, Alawi KM, Rodrigues J, Singh A, Kusumbe AP, Ramasamy SK.

Endothelial proteolytic activity and interaction with non-resorbing osteoclasts mediate bone elongation.

Nat Cell Biol. 2019 Apr;21(4):430-441. doi: 10.1038/s41556-019-0304-7.

ANGIOCRINE SIGNALS IN METASTASIS

Singh A, Veeriah V, Xi P, Labella R, Chen J, Romeo SG, Ramasamy SK, Kusumbe AP.

Angiocrine signals regulate quiescence and therapy resistance in bone metastasis.

JCI Insight. 2019 Jul 11;4(13).pii: 125679. doi: 10.1172/jci.insight.125679.

BONE VASCULAR NICHES IN HSC LOSS

Duarte D, Hawkins ED, Akinduro O, Ang H, De Filippo K, Kong IY, Haltalli M, Ruivo N, Straszkowski L, Vervoort SJ, McLean C, Weber TS, Khorshed R, Pirillo C, Wei A, Ramasamy SK, Kusumbe AP, Duffy K, Adams RH, Purton LE, Carlin LM, Lo Celso C.

Inhibition of Endosteal Vascular Niche Remodeling Rescues Hematopoietic Stem Cell Loss in AML.

Cell Stem Cell. 2018 Jan 4;22(1):64-77.e6. doi: 10.1016/j.stem.2017.11.006.

REVIEW OF BONE BLOOD VESSELS

Ramasamy SK.

Structure and Functions of Blood Vessels and Vascular Niches in Bone.

Stem Cells Int. 2017;2017:5046953. doi: 10.1155/2017/5046953.

BLOOD FLOW IN BONE

Ramasamy SK, Kusumbe AP, Schiller M, Zeuschner D, Bixel MG, Milia C, Gamrekelashvili J, Limbourg A, Medvinsky A, Santoro MM, Limbourg FP, Adams RH.

Blood flow controls bone vascular function and osteogenesis.

Nat Commun. 2016 Dec 6;7:13601. doi: 10.1038/ncomms13601.

BLOOD VESSEL SUBTYPES IN HAEMATOPOIESIS

Itkin T, Gur-Cohen S, Spencer JA, Schajnovitz A, Ramasamy SK, Kusumbe AP, Ledergor G, Jung Y, Milo I, Poulos MG, Kalinkovich A, Ludin A, Kollet O, Shakhar G, Butler JM, Rafii S, Adams RH, Scadden DT, Lin CP, Lapidot T.

Distinct bone marrow blood vessels differentially regulate haematopoiesis.

Nature. 2016 Apr 21;532(7599):323-8. doi: 10.1038/nature17624.

AGEING OF HSC VASCULAR NICHES

Kusumbe AP, Ramasamy SK, Itkin T, Mäe MA, Langen UH, Betsholtz C, Lapidot T, Adams RH.

Age-dependent modulation of vascular niches for haematopoietic stem cells.

Nature. 2016 Apr 21;532(7599):380-4. doi: 10.1038/nature17638.

REVIEW ON ANGIOCRINE FUNCTIONS

Ramasamy SK, Kusumbe AP, Adams RH.

Regulation of tissue morphogenesis by endothelial cell-derived signals.

Trends Cell Biol. 2015 Mar;25(3):148-57. doi: 10.1016/j.tcb.2014.11.007.

IDENTIFICATION OF NOTCH FUNCTION IN BONE VASCULATURE

Ramasamy SK, Kusumbe AP, Wang L, Adams RH.

Endothelial Notch activity promotes angiogenesis and osteogenesis in bone.

Nature. 2014 Mar 20;507(7492):376-380. doi: 10.1038/nature13146.

DISCOVERY OF TYPE-H VESSELS

Kusumbe AP, Ramasamy SK, Adams RH.

Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone.

Nature. 2014 Mar 20;507(7492):323-328. doi: 10.1038/nature13145.